Liquid biopsy in cancer – Molecular, genetic and genomic biomarkers – Circulating nucleosomes

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Molecular, genetic and genomic biomarkers

Circulating nucleosomes

Published 29 May 2025

Nucleosomes are fragments of DNA wrapped around a histone protein core which are released into the blood stream, primarily from dying cells. Depending on the analysis carried out tests for circulating nucleosomes can provide different types of information which may be used in cancer diagnosis. In addition to the quantitative analysis of nucleosome levels they may contain tumour specific genetic mutations or histone modifications (acetylation, methylation), that may be altered in cancer.

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