Liquid biopsy in cancer – Protein biomarkers – Serum TK1 (Thymidine Kinase 1) – dogs
spotlight topic:
Protein biomarkers
Dogs
Published 29 May 2025
- von Euler, H.P. et al. (2006) A non-radiometric method for measuring serum thymidine kinase activity in malignant lymphoma in dogs. Research in Veterinary Science, 80 (1), pp. 17–24. https://doi.org/10.1016/j.rvsc.2005.05.001
- von Euler, H.P. (1992) Monitoring therapy in canine malignant lymphoma and leukemia with serum thymidine kinase 1 activity – Evaluation of a new, fully automated non-radiometric assay. International Journal of Oncology, https://doi.org/10.3892/ijo_00000175
- von Euler, H.P. et al. (2004) Serum thymidine kinase activity in dogs with malignant lymphoma: A potent marker for prognosis and monitoring the disease. Journal of Veterinary Internal Medicine, 18 (5), p. 696-702. https://doi.org/10.1111/j.1939-1676.2004.tb02608.x
- Kim, Y. et al. (2024) Serum thymidine kinase 1 protein concentrations and presence of its autoantibody as biomarkers for screening dogs with malignant tumors. Journal of Veterinary Internal Medicine, 38 (1), pp. 300-307. https://doi.org/10.1111/jvim.16946
- Kim, Y. et al. (2025) Use of thymidine kinase 1 autoantibody, thymidine kinase antigen, extracellular protein kinase A autoantibody, and C‐reactive protein for early detection of malignant tumors in dogs.Journal of Veterinary Internal Medicine, 39 (1). https://doi.org/10.1111/jvim.17266
- Boyé, P. et al. (2019) Evaluation of serum thymidine kinase 1 activity as a biomarker for treatment effectiveness and prediction of relapse in dogs with non‐Hodgkin lymphoma. Journal of Veterinary Internal Medicine, 33 (4), pp. 1728–1739. https://doi.org/10.1111/jvim.15513
- Nakamura, N. et al. (1997) Plasma thymidine kinase activity in dogs with lymphoma and leukemia. Journal of Veterinary Medical Science, 59 (10), pp. 957–960. https://doi.org/10.1292/jvms.59.957
- Sharif, H. et al. (2023) A monoclonal antibody-based sandwich ELISA for measuring canine Thymidine kinase 1 protein and its role as biomarker in canine lymphoma. Frontiers in Veterinary Science, 10. https://doi.org/10.3389/fvets.2023.1243853
- Saellström, S. et al. (2022) Serum TK1 protein and C-reactive protein correlate to treatment response and predict survival in dogs with hematologic malignancies. Research in Veterinary Science, 145, pp. 213-221. https://doi.org/10.1016/j.rvsc.2022.02.019
- Thamm, D. H. et al. (2011) Elevated serum thymidine kinase activity in canine splenic hemangiosarcoma. Veterinary and Comparative Oncology, 10 (4), pp. 292–302. https://doi.org/10.1111/j.1476-5829.2011.00298.x
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