Responsible use of antiparasitic medications in veterinary practice: Lack of efficacy and resistance

spotlight topic:

2. Lack of efficacy and resistance

Published 16 June 2023

How well antiparasitic products work in practice may depend on a number of factors relating to the appropriate use at the right time in the life cycle of the parasite. It is important to be aware that not all treatment failure relates to the development of resistance to the product.

  • Geurden, T. et al. (2022) World Association for the Advancement of Veterinary Parasitology (WAAVP) guideline for the evaluation of the efficacy of anthelmintics in food-producing and companion animals: general guidelines. Veterinary Parasitology, 304, p. 109698. https://doi.org/10.1016/j.vetpar.2022.109698
  • Marchiondo, A.A. et al. (2013) World Association for the Advancement of Veterinary Parasitology (WAAVP) second edition: guidelines for evaluating the efficacy of parasiticides for the treatment, prevention and control of flea and tick infestations on dogs and cats. Veterinary Parasitology, 194 (1), pp. 84-97. https://doi.org/10.1016/j.vetpar.2013.02.003
  • Otranto, D. et al. (2021) World Association for the Advancement of Veterinary Parasitology (WAAVP) guidelines for studies evaluating the efficacy of parasiticides in reducing the risk of vector-borne pathogen transmission in dogs and cats. Veterinary Parasitology, 290, p. 109369. https://doi.org/10.1016/j.vetpar.2021.109369
  • Beugnet, F. et al. (2022) World Association for the Advancement of Veterinary Parasitology (WAAVP): Second edition of guidelines for evaluating the efficacy of anthelmintics for dogs and cats. Veterinary Parasitology, 312, p. 109815. https://doi.org/10.1016/j.vetpar.2022.109815
  • Kaplan, R.M. et al. (2023) World Association for the Advancement of Veterinary Parasitology (WAAVP) guideline for diagnosing anthelmintic resistance using the faecal egg count reduction test in ruminants, horses and swine. Veterinary Parasitology, 318, p. 109936. https://doi.org/10.1016/j.vetpar.2023.109936
  • Other guidelines from WAAVP are available from: Antiparasitic guidelines [WAAVP] [online]. Available from: https://www.waavp.org/antiparasitic-guidelines/published-guidelines.html [Accessed 8 June 2023]
  • McNair, C.M. (2015) Ectoparasites of medical and veterinary importance: drug resistance and the need for alternative control methods. Journal of Pharmacy and Pharmacology, 67 (3), pp.351-36. https://doi.org/10.1111/jphp.12368
  • Kaplan, R.M. (2004) Drug resistance in nematodes of veterinary importance: a status report. Trends in Parasitology, 20 (10), pp.477-481. https://doi.org/10.1016/j.pt.2004.08.001
  • Morgan, E.R. et al. (2022) Confounding factors affecting faecal egg count reduction as a measure of anthelmintic efficacy. Parasite29, no. 20. https://doi.org/10.1051%2Fparasite%2F2022017
  • Denwood, M.J. et al. (2023) A statistical framework for calculating prospective sample sizes and classifying efficacy results for faecal egg count reduction tests in ruminants, horses and swine. Veterinary Parasitology, 314, p.109867. https://doi.org/10.1016/j.vetpar.2022.109867

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