Cannabidiol: Pharmacokinetics in dogs and cat

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Pharmacokinetics in dogs and cat

Published 23 April 2023 | Updated 29 September 2023

  • Fernández-Trapero, M. et al. (2020) Pharmacokinetics of Sativex® in dogs: Towards a potential cannabinoid-based therapy for canine disorders. Biomolecules, 10 (2), no. 279.
  • Wakshlag, J.J. et al. (2020) Pharmacokinetics of cannabidiol, cannabidiolic acid, Δ9-tetrahydrocannabinol, tetrahydrocannabinolic acid and related metabolites in canine serum after dosing with three oral forms of hemp extract. Frontiers in Veterinary Science, 7.
  • Della Rocca, G. et al. (2022) Pharmacokinetics of cannabidiol following single oral and oral transmucosal administration in dogs. Frontiers in Veterinary Science, 9.
  • Di Salvo, A., Conti, M.B. and della Rocca, G. (2023) Pharmacokinetics, efficacy, and safety of cannabidiol in dogs: an update of current knowledge. Frontiers in Veterinary Science, 10,
  • Bartner, L.R. et al. (2018) Pharmacokinetics of cannabidiol administered by 3 delivery methods at 2 different dosages to healthy dogs. Canadian Journal of Veterinary Research, 82 (3), pp. 178-183. Available from: [Accessed 23 April 2023]
  • Amstutz, K. et al. (2022) Single dose and chronic oral administration of cannabigerol and cannabigerolic acid‐rich hemp extract in fed and fasted dogs: Physiological effect and pharmacokinetic evaluation. Journal of Veterinary Pharmacology and Therapeutics, 45 (3), pp. 245-254.
  • Polidoro, D. et al. (2022) Pharmacokinetics of cannabidiol following intranasal, intrarectal, and oral administration in healthy dogs. Frontiers in Veterinary Science, 9.
  • Deabold, K.A. et al. (2019) Single-dose pharmacokinetics and preliminary safety assessment with use of CBD-rich hemp nutraceutical in healthy dogs and cats. Animals, 9 (10), no. 832.
  • Jukier, T et al. (2023) Disposition of a single oral dose of a cannabidiol medication in healthy cats Frontiers in Veterinary Science, 10.
  • Rozental, A.J. et al. (2023) Pharmacokinetics of escalating single‐dose administration of cannabidiol to cats. Journal of Veterinary Pharmacology and Therapeutics, 46 (1), pp. 25-33.
  • Court, M.H. et al. (2023) Cannabidiol and cannabidiolic acid: Preliminary in vitro evaluation of metabolism and drug–drug interactions involving canine cytochrome P‐450, UDP‐glucuronosyltransferase, and P‐glycoprotein. Journal of Veterinary Pharmacology and Therapeutics,
  • Doran, C.E. et al. (2022) Drug-drug interaction between cannabidiol and phenobarbital in healthy dogs. American Journal of Veterinary Research, 83 (1).

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