Efficacy and safety of enflicoxib for treatment of canine osteoarthritis

Journal club resource:

Efficacy and safety of enflicoxib for treatment of canine osteoarthritis: A 6‐week randomised, controlled, blind, multicentre clinical trial.

Salichs, M. et al (2021) Efficacy and safety of enflicoxib for treatment of canine osteoarthritis: A 6‐week randomised, controlled, blind, multicentre clinical trial. Veterinary Record, p. e949. https://doi.org/10.1002/vetr.949

[Open Access]


The objective of this prospective randomised controlled trial was to confirm the safety and efficacy of enflicoxib for the treatment of naturally occurring osteoarthritis (OA) in dogs. The study, which was carried out at 28 veterinary practices located throughout Spain and France, was funded by Ecuphar, manufacturers of enflicoxib and two of the authors work for Ecuphar.

In veterinary practice we are often reliant on studies funded by pharmaceutical companies, especially when it comes to new products. While randomised controlled trials are considered the most appropriate study design for comparing treatments, it is still important to critically appraise the study to assess any potential bias and consider how appropriate the findings are to your own patients.

The  December 2021 edition of inFOCUS contains a summary of this paper.

Support with assessing the relevance of this paper

We have produced a guide that you can use to work through this paper as a practice.  For those less confident in assessing published papers there is a partially completed guide.

Working through this guide will help you pick out points that can help you assess the efficacy and safety of this product as well as help you build confidence in assessing  other papers reporting on efficacy and safety of veterinary medicines more widely.

For those new to journal clubs, we have a step-by-step guide you might find useful: Setting up and running a journal club

Further Reading

Wareham, K.J. et al (2017) Sponsorship bias and quality of randomised controlled trials in veterinary medicine. BMC Veterinary Research, 13, no. 234 . https://doi.org/10.1186/s12917-017-1146-9

European Medicines Agency: Committee for Medicinal Products for Veterinary Use (2021) CVMP assessment report for Daxocox.  Available from: https://www.ema.europa.eu/en/documents/assessment-report/daxocox-epar-public-assessment-report_en.pdf [Accessed 4 February 2022]

Veterinary Medicines Directorate (2021) Summary of Product Characteristics Daxocox. Available from: https://www.vmd.defra.gov.uk/ProductInformationDatabase/files/SPC_Documents/SPC_2050514.PDF [Accessed 4 February 2022]

Homedes, J., Salichs, M. and Guzman, A. (2021) Long-term safety evaluation of Daxocox® tablets (enflicoxib) in dogs after weekly oral administrations for seven months. BMC Veterinary Research, 17 no. 205. https://doi.org/10.1186/s12917-021-02910-0

Hunt, J.R. et al (2015) An analysis of the relative frequencies of reported adverse events associated with NSAID administration in dogs and cats in the United Kingdom. The Veterinary Journal, 206 (2), pp. 183-190. https://doi.org/10.1016/j.tvjl.2015.07.025

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