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A prospective, randomized, placebo-controlled, double-blinded clinical trial comparing the incidence and severity of gastrointestinal adverse events in dogs with cancer treated with piroxicam alone or in combination with omeprazole or famotidine

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M.H. Shaevitz, G.E. Moore and C.M. Fulkerson | Journal of the American Veterinary Medical Association | August 2021
The aim of this randomised placebo-controlled, double-blinded trial, which was carried at a Veterinary Teaching Hospital in the United States and funded by the Veterinary Cancer Society’s Resident Research Award, was to assess the impact of prophylactic administration of omeprazole or famotidine on the incidence and severity of gastrointestinal (GI) adverse events (AEs) in dogs with cancer treated with piroxicam…

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Prediction of clinically important acquired cardiac disease without an echocardiogram in large breed dogs using a combination of clinical, radiographic and electrocardiographic variables

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S. Wesselowski, S.G. Gordon, N. Meddaugh, A.B. Saunders, J. Häggström, K. Cusack, B.W. Janacek and D.J. Matthews | Journal of Veterinary Cardiology | August 2021
The objectives of this retrospective study were to (1) assess the clinical utility of thoracic radiographs and (2) to explore the potential utility of prediction models incorporating radiographic measurements, physical examination (PE) and electrocardiogram (ECG) to predict clinically important dilated cardiomyopathy (DCM) or myxomatous mitral valve disease (MMVD) in the absence of an echocardiogram in large-breed (LB) dogs…

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A prospective, randomized, blinded, placebo-controlled multisite clinical study of bedinvetmab , a canine monoclonal antibody targeting nerve growth factor, in dogs with osteoarthritis

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M.J. Corral, H. Moyaert, T. Fernandes, M. Escalada, J.K.S. Tena, R. R. Walters and M.R. Stegemann | Veterinary Anaesthesia and Analgesia | August 2021
The aim of this randomized, double-blind, multicentre study was to evaluate the efficacy and safety of bedinvetmab (Librela; Zoetis), compared to a placebo, for the alleviation of pain associated with osteoarthritis in client-owned dogs (n = 287)…

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Laboratory safety evaluation of bedinvetmab, a canine anti-nerve growth factor monoclonal antibody, in dogs

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M. Krautmann, R. Walters, P. Cole, J. Tena, L.M. Bergeron, J. Messamore, D. Mwangi, S. Rai, P. Dominowski, K. Saad, Y. Zhu, M. Guillot and L. Chouinard | The Veterinary Journal | October 2021
This paper describes the laboratory safety evaluation of bedinvetmab based on three integrated laboratory studies in healthy adult laboratory Beagles…

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